2019-07-10
Información sobre el medicamento de Sofosbuvir / Velpatasvir / Voxilaprevir para pacientes y consumidores.
Sofosbuvir and velpatasvir is a combination antiviral medicine used to treat chronic hepatitis C in adults and children at least 6 years old or weighing at least 37 pounds (17 kilograms). This medicine is sometimes given in combination with another antiviral medicine called ribavirin in … Sofosbuvir/velpatasvir, sold under the brand name Epclusa among others, is a fixed-dose combination medication for the treatment of hepatitis C in adults. It combines sofosbuvir and velpatasvir. It is more than 90% effective for hepatitis C genotypes one through six.
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Sofosbuvir is in a class of antiviral medications called nucleotide hepatitis C virus (HCV) NS5B polymerase inhibitors. Velpatasvir is in a class of antiviral medications called HCV NS5A replication complex inhibitors.
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What is sofosbuvir/velpatasvir? What is sofosbuvir/velpatasvir?
2021-04-01
The most common adverse effects, observed in at least 10% of phase 3 trial participants, were headache Class and Mechanism. Sofosbuvir-Velpatasvir is an oral fixed-dose combination of sofosbuvir, a nucleotide analog NS5B Manufacturer for United What is sofosbuvir and velpatasvir? Sofosbuvir and velpatasvir is a combination antiviral medicine used to treat chronic hepatitis C in adults and children at least 6 years old or weighing at least 37 pounds (17 kilograms). sofosbuvir and velpatasvir is sometimes given in combination with another antiviral medicine called ribavirin in people who also have advanced cirrhosis. Epclusa är ett läkemedel som innehåller de aktiva substanserna sofosbuvir och velpatasvir i en enda tablett. Det ges för att behandla en kronisk (långvarig) virusinfektion i levern som kallas hepatit C, hos patienter i åldern 6 år och äldre, och som väger minst 17 kg. EPCLUSA (sofosbuvir 400 mg/velpatasvir 100 mg, sofosbuvir 200 mg/velpatasvir 50 mg tablets) is indicated for the treatment of patients 6 years of age and older or weighing at least 17 kg with chronic hepatitis C virus (HCV) genotype 1, 2, 3, 4, 5, or 6 infection without cirrhosis or with compensated cirrhosis and in combination with ribavirin for those with decompensated cirrhosis.
The most common adverse effects, observed in at least 10% of phase 3 trial participants, were headache Class and Mechanism. Sofosbuvir-Velpatasvir is an oral fixed-dose combination of sofosbuvir, a nucleotide analog NS5B Manufacturer for United
What is sofosbuvir and velpatasvir? Sofosbuvir and velpatasvir is a combination antiviral medicine used to treat chronic hepatitis C in adults and children at least 6 years old or weighing at least 37 pounds (17 kilograms). sofosbuvir and velpatasvir is sometimes given in combination with another antiviral medicine called ribavirin in people who also have advanced cirrhosis. Epclusa är ett läkemedel som innehåller de aktiva substanserna sofosbuvir och velpatasvir i en enda tablett. Det ges för att behandla en kronisk (långvarig) virusinfektion i levern som kallas hepatit C, hos patienter i åldern 6 år och äldre, och som väger minst 17 kg.
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¿Cómo se debe usar este medicamento? Sofosbuvir and velpatasvir are substrates of drug transporters P-gp and BCRP while GS-331007 (the predominant circulating metabolite of sofosbuvir) is not In vitro, slow metabolic turnover of velpatasvir by CYP2B6, CYP2C8, and CYP3A4 was observed Sofosbuvir and velpatasvir treats specific genotypes of hepatitis C, and only in certain people.
Sofosbuvir and velpatasvir is indicated for the treatment of adults and pediatric patients 6 years of age and older or weighing at least 17 kg with chronic hepatitis C virus (HCV) genotype 1, 2, 3, 4, 5, or 6 infection [see Dosage and Administration (2.2, 2.3, 2.4) and Clinical Studies (14)]: without cirrhosis or with compensated cirrhosis
Sofosbuvir /velpatasvir is a prescription medicine approved by the U.S. Food and Drug Administration (FDA) for the treatment of chronic (lasting a long time) hepatitis C virus infection (HCV). HCV is an opportunistic infection (OI) of HIV.
Sofosbuvir, velpatasvir, and voxilaprevir (Vosevi) is a combination antiviral medicine that is used to treat chronic hepatitis C in adults.
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Epclusa (sofosbuvir/velpatasvir fixed-dose combination) is indicated for the treatment of chronic hepatitis C virus (HCV) infection (genotype 1, 2, 3, 4, 5 or 6) in adults. (see DOSAGE AND ADMINISTRATION section for the recommended regimens for different patient subgroups).
Results: Forty-four per cent of patients had cirrhosis. Sustained virological response 12 weeks after treatment was achieved by 98% of … EPCLUSA (sofosbuvir 400 mg/velpatasvir 100 mg, sofosbuvir 200 mg/velpatasvir 50 mg tablets) is indicated for the treatment of patients 6 years of age and older or weighing at least 17 kg with chronic hepatitis C virus (HCV) genotype 1, 2, 3, 4, 5, or 6 infection without cirrhosis or with compensated cirrhosis and in combination with ribavirin for those with decompensated cirrhosis. 2021-03-26 2018-11-14 Sofosbuvir is a nucleotide analogue inhibitor and velpatasvir is an HCV inhibitor; they reduce viral load by inhibiting hepatitis C virus RNA replication. Indications and dose Chronic hepatitis C infection, with or without ribavirin (initiated by a specialist) Four patients (8%) who received sofosbuvir-velpatasvir and seven (14%) who received sofosbuvir-velpatasvir plus ribavirin experienced a serious AE. The 3 deaths (bacterial sepsis, gastric varices hemorrhage, hepatocellular carcinoma) were attributed to liver disease progression.
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Sofosbuvir+Velpatasvir (Sofosvel) Sofosvel is the global first generic oral tablet for pan-genotypic Chronic Hepatitis C treatment. This combination (Sofosbuvir 400 mg + Valpatasvir 100 mg) drug has been approved by US FDA & European Commission for treatment of patients with all genotypic Chronic Hepatitis C virus infection.
What is Epclusa and what is it used for? Epclusa is an antiviral medicine used to treat patient s from 6 years of age and weighing at least 17 kg with chronic (long-term) hepatitis C, an infectious disease that affects the liver, caused by the hepatitis 2016-03-23 2021-04-01 2021-04-06 Sofosbuvir/velpatasvir fixed-dose combination for the treatment of chronic hepatitis C virus infection. Nehra V(1), Rizza SA(2), Temesgen Z(3). Author information: (1)Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA. Guidelines recommend 1 tablet (400 mg sofosbuvir; 100 mg velpatasvir) PO once daily for 24 weeks as a preferred treatment regimen. Recommendation includes patients who may or may not be candidates for liver transplant, including those with hepatocellular carcinoma. Adults in whom prior sofosbuvir- or NS5A-based treatment failed† Sofosbuvir and velpatasvir are substrates of drug transporters P-gp and BCRP.
Sofosbuvir and velpatasvir is a combination antiviral medicine used to treat chronic hepatitis C in adults and children at least 6 years old or weighing at least 37 pounds (17 kilograms). sofosbuvir and velpatasvir is sometimes given in combination with another antiviral medicine called ribavirin in people who also have advanced cirrhosis.
För fullständig förteckning över hjälpämnen, se avsnitt 6.1. 3. LÄKEMEDELSFORM.
Adults in whom prior sofosbuvir- or NS5A-based treatment failed† Sofosbuvir and velpatasvir are substrates of drug transporters P-gp and BCRP.